National Toxicology Program

CASRN: 9002-89-5

Formula: (C3-H4-0)X

Synonyms/Common Names:

• HOMOPOLYMER ETHANOL (9CI)
• VINYL ALCOHOL, POLYMERS (8CI)

Known Uses:

PVA FILM FOR INTRAVAGINAL ADMINISTRATION OF SPERMICIDES. TEXTILE WARP SIZING AND FINISHING. ADHESIVES. PESTICIDES. PIGMENT IN TV PICTURE TUBES.

Short-Term Toxicity

• 4-WEEK (Intravaginal)  (C88066) Completed 
  • NTIS No. PB98-148869  (Peer Review 12/12/1996)
    Citation: Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CAS No.9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies)
  • Mice: B6C3F1
  • Dose: 0, 20 UL OF 25% PVA - NO RESTRAINT, 20 UL OF 25% PVA WITH RESTRAINT; 50/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Intravaginal)  (C88066) Report Complete 
  • TR-474 (NTIS No. PB98-148869)  (Peer Review 12/12/1996)
    Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CAS No.9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Female Mice No Evidence 
  • Dose: 25% PVA, VEHICLE, UNTREATED; 100/GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Intravaginal)  (S0695) Completed 
  • Citation: SANDERS, J.M. & MATTHEWS, H.B. VAGINAL ABSORPTION OF POLYVINYL ALCOHOL IN FISCHER 344 RATS HUMAN HUMAN TOXICOLOGY (1990) 9, 000-000
  • M Rats: F344/N; M Rats: F344/N; F Rats: F344/N