National Toxicology Program

CASRN: 57-74-9

Related: 12789-03-6

Formula: C10-H6-CL8

Synonyms/Common Names:

• 4,7-METHANO-1H-INDENE,1,2,4,5,6,7,8,8-OCTACHLORO-2,3,3A,7,7A-HEXAHYDRO (9CI)

Known Uses:

INSECTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00099) Completed 
  • NTIS No. PB271977  (Peer Review NA)
    Citation: Bioassay of Chlordane for Possible Carcinogenicity (CAS No. 57-74-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00099) Completed 
  • NTIS No. PB271977  (Peer Review NA)
    Citation: Bioassay of Chlordane for Possible Carcinogenicity (CAS No. 57-74-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: MR: 0,50,1600, FR: 0,100,1600, M: 0,20,640 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00099) Report Complete 
  • TR-008 (NTIS No. PB271977)  (Peer Review NA)
    Bioassay of Chlordane for Possible Carcinogenicity (CAS No. 57-74-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: FR: 0,120.8,241.5 (AVG), MR: 0,203.5,407 (AVG), FM: 0,30.1,63.8 (AVG), MM: 0,29.9,56.2 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (675840) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (779361) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative