Testing Information

Testing Status of Agents at NTP

Emodin

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http://ntp.niehs.nih.gov/go/TS-518821

CASRN: 518-82-1

Formula: C15-H10-O5

Synonyms/Common Names:

  • 1,3,8-TRIHYDROXY-6-METHYL-9,10-ANTHRACENEDIONE (9CI)
  • 1,3,8-TRIHYDROXY-6-METHYLANTHRAQUINONE

Known Uses:

MAJOR COMPONENT OF NATURAL LAXATIVE DRUGS OF PLANT ORIGIN. MEDICINE. NATURAL PLANT DYE. (2,3)

Short-Term Toxicity

  • 2-WEEK (Dosed-Feed)  (C62408) Completed 
    • NTIS No. PB2001-108194  (Peer Review 05/21/1999)
      Citation: Toxicology and Carcinogenesis Studies of Emodin (CAS No. 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.06, 0.2, 0.55, 1.2, OR 5% IN FEED
  • 13-WEEK (Dosed-Feed)  (C62408) Completed 
    • NTIS No. PB2001-108194  (Peer Review 05/21/1999)
      Citation: Toxicology and Carcinogenesis Studies of Emodin (CAS No. 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.03, 0.06, 0.125, 0.25, OR 0.5% IN FEED

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C62408) Report Complete 
    • TR-493 (NTIS No. PB2001-108194)  (Peer Review 05/21/1999)
      Toxicology and Carcinogenesis Studies of Emodin (CAS No. 518-82-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 280, 830, OR 2500 PPM; 60/SEX M: 0, 160, 312, 625, OR 1250 PPM; 60/SEX

Special Studies

  • Toxicokinetic Study (Intravenous; Gavage)  (S0322) Completed 
    • Citation: NO PUBLICATION IS PLANNED, WILL BE REPORTED AS PART OF THE TR
    • M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N
    • Dose: RATS & MICE IV 2 MG/KG BW; GAV 20 & 150 MG/KG BW
  • Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (S0575) Completed 
    • M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1; M/F Rats: F344/N; M/F Mice: B6C3F1
    • Dose: 90D: 0.03, 0.06, 0.125, 0.25 OR 0.5% IN FEED, BLOOD, PAR; 104W: RAT 280, 830 OR 2500 PPM, MICE 160, 312, 625 OR 1250 PPM IN FEED, BLOOD,90D: FEED,BLOOD,104W: FEED,BLOOD,

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A00749) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Not Tested 
  • Micronucleus  (A43429) Completed 
    • Rats: F344
    • Male Negative 
  • Micronucleus  (A58400) Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Micronucleus  (A88319) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (278686) Completed 
    •  Weakly Positive 
  • Salmonella  (399853) Completed 
    •  Positive 

Organ Systems Toxicity

  • GD 6-20 Conventional Teratology (Dosed-Feed)  (TER98003) Completed 
    • NTIS No. PB2002-108975
      Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CAS NO. 518-82-1) ADMINISTERED IN THE FEED TO?SPRAGUE DAWLEY (CD®) RATS ON GESTATIONAL DAYS 6 TO 20
    • NTIS No. PB2002-108976
      Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CAS NO. 518-82-1) ADMINISTERED IN THE FEED TO?SPRAGUE DAWLEY (CD®) RATS ON GESTATIONAL DAYS 6 TO 20
    • F Rats: Sprague Dawley
    • Dose: 0, 425, 850, OR 1700 PPM
  • GD 6-17 Conventional Teratology (Dosed-Feed)  (TER99003) Completed 
    • NTIS No. PB2002-108977
      Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CAS NO. 518-82-1) ADMINISTERED IN THE FEED TO?SWISS (CD-1®) MICE ON GESTATIONAL DAYS 6 TO 17
    • NTIS No. PB2002-108978
      Citation: DEVELOPMENTAL TOXICITY EVALUATION OF EMODIN?(CAS NO. 518-82-1) ADMINISTERED IN THE FEED TO?SWISS (CD-1®) MICE ON GESTATIONAL DAYS 6 TO 17
    • F Mice: Swiss CD-1
    • Dose: 0, 600, 2500, OR 6000 PPM
  • GD 6-20 Teratology Pilot Studies (Dosed-Feed)  (TRP98003) Completed 
    • F Rats: Sprague Dawley
    • Dose: 0, 1700, 3400, 6750, 10,000 OR 13,500 PPM
  • GD 6 TO 17 Teratology Pilot Studies (Dosed-Feed)  (TRP99006) Completed 
    • F Mice: Swiss CD-1
    • Dose: 0, 750, 1500, 3000, 4500, OR 6000 PPM

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Web page last updated on January 22, 2009