Testing Status of Agents at NTP
t-Butylhydroquinone
CASRN: 1948-33-0
Formula: C10-H14-O2
Synonyms/Common Names:
- 1,4-BENZENEDIOL, 2-(1,1-DIMETHYLETHYL)
- MTBHQ
Known Uses:
ANTIOXIDANT IN VEGETABLE FATS AND OILS. INTERMEDIATE. (TDB)
Short-Term Toxicity
- 13-WEEK (Dosed-Feed)
(C62157) Completed
- NTIS No. PB98-107170
(Peer Review 06/20/1995)
Citation: Toxicology and Carcinogenesis Studies oft-Butylhydroquinone (CAS No. 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.25, 0.5, 1.0, 2.0, OR 4.0% IN FEED
- NTIS No. PB98-107170
(Peer Review 06/20/1995)
Long-Term Carcinogenicity
- LIFETIME (Dosed-Feed)
(C62157) Report Complete
- TR-459 (NTIS No. PB98-107170)
(Peer Review 06/20/1995)
Toxicology and Carcinogenesis Studies oft-Butylhydroquinone (CAS No. 1948-33-0) in F344 Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1; Rats: F344/N
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 0.125, 0.25, OR 0.5% IN FEED; 70 RATS, 60 MICE
- TR-459 (NTIS No. PB98-107170)
(Peer Review 06/20/1995)
Genetic Toxicology
- Chromosome Aberrations
(A73022) Completed
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(089956) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Micronucleus
(A34876) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(663851) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
- Salmonella
(A71156) Completed
- Inconclusive
Organ Systems Toxicity
- Immunotoxicity (Gavage)
(IMM87036) Completed
- F Mice: B6C3F1
- Dose: 0, 25, 75, 150 MG/KG
Web page last updated on January 22, 2009