Testing Status of Agents at NTP
Gallium arsenide
CASRN: 1303-00-0
Formula: AS-GA
Synonyms/Common Names:
- GALLIUM MONOARSENIDE
Known Uses:
SEMICONDUCTORS. MAGNETORESISTANCE DEVICES. LIGHT-EMITTING DIODES. MICROWAVE GENERATION. (TDB)
Short-Term Toxicity
- 2-WEEK (Inhalation)
(C62033) Completed
- NTIS No. PB2001-102003
Citation: Toxicology and Carcinogenesis Studies of Gallium Arsenide (CAS No. 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R & M: 0, 1, 10, 37, 75 OR 150 MG/M3 (5/S/S)
- NTIS No. PB2001-102003
- 13-WEEK (Inhalation)
(C62033) Completed
- NTIS No. PB2001-102003
Citation: Toxicology and Carcinogenesis Studies of Gallium Arsenide (CAS No. 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M:0,0.1,1,10,37,75 MG/M3/20 & 10 PER GROUP RESPECTIVELY
- NTIS No. PB2001-102003
Long-Term Carcinogenicity
- 2-YEAR (Inhalation)
(C62033B) Report Complete
- TR-492 (NTIS No. PB2001-102003)
(Peer Review 05/21/1999)
Toxicology and Carcinogenesis Studies of Gallium Arsenide (CAS No. 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats Clear Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 0.01, 0.1, OR 1.0 MG/M3; 50/SEX/GROUP M: 0, 0.1, 0.5, OR 1.0 MG/M3; 50/SEX/GROUP
- TR-492 (NTIS No. PB2001-102003)
(Peer Review 05/21/1999)
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)
(S0144) Completed
- Citation: CARTER, D.E. & BELLAMY, W.T.: TOXICOLOGY OF THE GROUP III-V INTERMETALLIC SEMICONDUCTOR, GALLIUM ARSENIDE,"BIOLOGICAL MONITORING OF TOXIC METALS", T.W. CLARKSON, L. FRIEBERG, G.F. NORDBERG & P.S. SAGER, (EDS.), PLENUM PUBLISHING CORP., P. 455-468, 1988.
- M Rats; M Rats
- Dose: PO:10,100,1000 INTRATRACHEAL:100 MG/KG
- Absorption Disposition Metabolism Elimination (Intratracheal)
(S0444) Completed
- Citation: WEBB, D.R., ET.AL., PULMONARY CLEARANCE & TOXICITY OF RESPIRABLE GAAS PARTICULATES INTRATRACHEALLY INSTILLED INTO RATS, AM IND HYG ASSOC 48(7):660-667, 1987***** WEBB, ET.AL., COMPARATIVE PULMONARY TOXICITY OF GAAS, GA(III) OXIDE OR AS(III) OXIDE INTRATRACHEALLY INSTILLED IN RATS, TOXICOL & APPL PHARM 82:405-416,1986.
- M Rats: F344/N
- Dose: 100 mg/kg
- Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)
(S0445) Completed
- Citation: WEBB, D.R., ET.AL., IN VITRO SOLUBILITY & INVIVO TOXICITY OF GALLIUM ARSENIDE, TOXICOL & APPL PHARM 76:96-104, 1984.
- M Rats: F344/N; M Rats: F344/N
- Dose: 10, 100, or 1000 mg/kg for gavage. 10, 30, or 100 mg/kg for Intratracheal
- Absorption Disposition Metabolism Elimination (Intratracheal)
(S0470) Completed
- Citation: ROSNER, M.H. & CARTER, D.E., METABOLISM & EXCRETION OF GAAS & AS OXIDES BY HAMSTERS FOLLOWING INTRTRACHEAL INSTILLATION, FUND & APPL TOXICOL 9:730-737,1987.
- M Hamsters: Syrian Golden
- Absorption Disposition Metabolism Elimination (Gavage; Intratracheal)
(S0766) Completed
- Citation: FINAL REPORT OF CONTRACT # N01-ES-8-2130. BY SIPED, ILGL, & CARTER, DE.
- Rats; Rats
- Dose: gavage, 10, 100 or 1000 mg/kg. intratracheal 10, 30, 0r 100 mg/kg
- Absorption Disposition Metabolism Elimination (Intratracheal)
(S0767) Completed
- Citation: WEBB, D.R., WILSON, S.E., & CARTER, D.E. PULMONARY CLEARANCE AND TOXICITY OF RESPIRABLE GALLIUM ARSENIDE PARTICULATES INTRATRACHEALLY INSTILLED INTO RATS. AM. IND. HYG. ASOC J 48 (7): 660-667 (1987)
- M Rats: F344/N
- Toxicokinetic Study (Inhalation)
(S0564) Completed
- M/F Rats: F344/N; M/F Mice: B6C3F1
- Dose: RAT: 0, 0.01, 0.1, & 1.0 MG/M3; MICE: 0, 0.1, 0.5, & 1.0 MG/M3
Genetic Toxicology
- Micronucleus
(A56833) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(006180) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Negative
Organ Systems Toxicity
- Immunotoxicity (Intratracheal)
(IMM90013) Completed
- NTIS No. PB92-140383
Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15 - Citation: SUMMARY (1-15)
- F Mice: B6C3F1
- Mice Female Positive
- Dose: 0, 50, 100, 200 MG/KG
- NTIS No. PB92-140383
- GD 4-19 Conventional Teratology (Inhalation)
(TER89143) Completed
- Citation: DE91005300/XAB
- Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 10, 37, 75 MG/CUBIC METER
- GD 4-17 Conventional Teratology (Inhalation)
(TER90043) Completed
- Citation: DE91005300/XAB
- F Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 10, 37, 75 MG/CUBIC METER
Web page last updated on January 22, 2009