Testing Information

Testing Status of Agents at NTP

Oxymetholone

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http://ntp.niehs.nih.gov/go/TS-11167-A

CASRN: 434-07-1

Formula: C21-H32-O3

Synonyms/Common Names:

  • 5ALPHA-ANDROSTAN-3-ONE,17BETA-HYDROXY-2-(HYDROXYMETHYLENE)- 17-METHYL- (8CI)
  • ANADROL
  • ANASTERONAL
  • (5ALPHA,17BETA)-17-HYDROXY-2-(HYDROXYMETHYLENE)-17-METHYL-ANDROSTAN-3-ONE (9CI)
  • NASTENON
  • OXIMETHOLONE
  • PAVISOID

Known Uses:

MAINTAIN A POSITIVE NITROGEN BALANCE. TO PROMOTE WEIGHT GAIN IN CACHEXIA, DEBILITATING DISEASES, SERIOUS INFECTIONS, BURNS, TRAUMA AND SURGERY. TREATMENT OF ANEMIAS. (NTP EXECUTIVE SUMMARY)

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C88032B) Completed 
    • NTIS No. PB2000-101419  (Peer Review 10/30/1998)
      Citation: Toxicology and Carcinogenesis Studies of Oxymetholone (CAS No. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 160, 315, 625, 1250, OR 2500 MG/KG; 5/SEX/GROUP M: 0, 320, 630, 1250, 2500, OR 5000 MG/KG; 5/SEX/GROUP
  • 2-WEEK (Dosed-Feed)  (C88032) Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.34, 0.67, 1.25, 2.50, OR 5% (5/SEX/SPECIES/GROUP)
  • 13-WEEK (Gavage)  (C88032B) Completed 
    • NTIS No. PB2000-101419  (Peer Review 10/30/1998)
      Citation: Toxicology and Carcinogenesis Studies of Oxymetholone (CAS No. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 80, 160, 315, 625, OR 1250 MG/KG; 20/SEX/GROUP M: 0, 160, 320, 630, 1250, OR 2500 MG/KG; 10/SEX/GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C88032B) Report Complete 
    • TR-485 (NTIS No. PB2000-101419)  (Peer Review 10/30/1998)
      Toxicology and Carcinogenesis Studies of Oxymetholone (CAS No. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Clear Evidence 
    • Dose: MR: 0, 3, 30, OR 150 MG/KG; FR: 0, 3, 30, OR 100 MG/KG

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Gavage)  (S0193) Completed 
    • Citation: NO REPORT WILL BE PUBLISHED / NO PUBLICATION(S) WILL BE FORTHCOMING.
    • M Rats: F344/N; M Rats: F344/N
    • Dose: 5, 50 mg/kg
  • Toxicokinetic Study (Intravenous; Gavage; Intravenous; Gavage)  (S0569) Completed 
    • M Rats: F344/N; M/F Rats: F344/N; M Mice: B6C3F1; M Mice: B6C3F1
    • Dose: (UNITS MG/KG BW): RATS: gav: males: 3, 30, 150; females: 3, 30, 100 mouse chronic cancelled.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A62570) Completed 
    • Chromosome Aberation Negative 
  • Micronucleus  (A29765) Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (990860) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 14 DAYS Immunotoxicity (Gavage)  (IMM90012) Completed 
    • NTIS No. PB92-140383
      Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Citation: SUMMARY (1-15)
    • F Mice: B6C3F1
    • Mice Female Negative 
    • Dose: 0, 50, 150, 300 MG/KG

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Web page last updated on January 22, 2009