National Toxicology Program

CASRN: 121-54-0

Formula: C27-H42-N-O2.CL

Synonyms/Common Names:

• N,N-DIMETHYL-N-(2-(2-(4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY)ETHOXY)ETHYL)BENZENEMETHANAMINIUM CHLORIDE (9CI)

Known Uses:

TOPICAL ANTI-INFECTIVE (VET) AND ANTISEPTIC. GERMICIDE FOR CLEANSING FOOD AND DAIRY UTENSILS. IN CONTROLLING SWIMMING POOL ALGAE AND DANDRUFF. (TDB)

Short-Term Toxicity

• 14-Day (Topical Application)  (C61494A) Completed 
  • NTIS No. PB96-162300
    Citation: Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CAS No. 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Topical Application)  (C61494A) Completed 
  • NTIS No. PB96-162300
    Citation: Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CAS No. 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,1.56,25.0 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C61494B) Report Complete 
  • TR-438 (NTIS No. PB96-162300)  (Peer Review 06/21/1994)
    Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CAS No. 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R&M: 0,0.15,0.5,1.5 MG/KG/50/GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0573) Completed 
  • Rats: F344/N; Rats: F344/N

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (173525) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (397650) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative 

Organ Systems Toxicity

• Immunotoxicity (Topical Application)  (IMM89007) Completed 
  • NTIS No. PB92-140383
    Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
  • Citation: SUMMARY (1-15)
  • F Mice: B6C3F1
  • Dose: 0, 1, 3, 10%
• GS 6-15 (COPULATORY PLUG = GD 0) Short-Term in vivo Repro. Tox. (Gavage)  (T0091) Completed 
  • F Mice: Swiss