National Toxicology Program

CASRN: 116-14-3

Formula: C2 F4

Synonyms/Common Names:

• ETHENE, TETRAFLUORO- (9CI)

Known Uses:

MONOMER FOR POLYTETRAFLUOROETHYLENE POLYMERS. PREPARATION OF PROPELLANTS FOR FOOD PRODUCT AEROSOLS. CHEMICAL INTERMEDIATE. (TDB)

Short-Term Toxicity

• 14-Day (Inhalation)  (C61596) Completed 
  • NTIS No. PB97-208508
    Citation: Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Inhalation)  (C61596) Completed 
  • NTIS No. PB97-208508
    Citation: Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,312,625,1250,2500,5000 PPM/010 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C61596B) Report Complete 
  • TR-450 (NTIS No. PB97-208508)  (Peer Review 12/05/1995)
    Toxicology and Carcinogenesis Studies of Tetrafluoroethylene (CAS No. 116-14-3) in F344 Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MICE & FR: 0, 312, 625, OR 1250 MR: 0, 156, 312, OR 625 PPM; 50/GROUP

Genetic Toxicology

• Micronucleus  (A09684) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative