Testing Information

Testing Status of Agents at NTP

2-Butoxyethanol (ethylene glycol monobutyl ether)

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http://ntp.niehs.nih.gov/go/TS-11135-T

CASRN: 111-76-2

Formula: C6-H14-O2

Synonyms/Common Names:

  • BUTOXYETHONOL
  • 2-BUTOXYETHANOL (9CI)
  • EGMBE

Known Uses:

SOLVENT FOR MINERAL OILS, IN SPRAY LACQUERS, VARNISH REMOVERS, AND INKS; IN DEGREASERS IN INDUSTRIAL AND HOUSEHOLD CLEANERS `

Short-Term Toxicity

  • 2-WEEK (Inhalation)  (C62077D) Completed 
    • NTIS No. PB2000-105865  (Peer Review 10/30/1998)
      Citation: Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 31, 62.5, 125, 250, 500, OR 1000 PPM; 5/SEX/SPECIES/GROUP
  • 2-WEEK (Dosed-Water)  (C62077) Completed 
    • TOX-26 (NTIS No. PB94-118106)  (Peer Review 12/01/1992)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1Mice
    • Rats: F344/N; Mice: B6C3F1
  • 8-WEEK (Dosed-Water)  (C62077C) Report Complete 
    • TOX-26 (NTIS No. PB94-118106)  (Peer Review 12/00/1992)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1Mice
    • Rats: F344/N
    • Dose: R: 0, 3000, 6000 PPM/20 PER GROUP
  • 13-WEEK (Inhalation)  (C62077D) Completed 
    • NTIS No. PB2000-105865  (Peer Review 10/30/1998)
      Citation: Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 31, 62.5, 125, 250, OR 500 PPM; 10/SEX/SPECIES/GROUP
  • 13-WEEK (Dosed-Water)  (C62077) Report Complete 
    • TOX-26 (NTIS No. PB94-118106)  (Peer Review 12/01/1992)
      Toxicity Studies of Ethylene Glycol Ethers 2-Methoxyethanol, 2-Ethoxyethanol, 2-Butoxyethanol (CAS Nos. 109-86-4, 110-80-5, 111-76-2) Administered in Drinking Water to F344/N Rats and B6C3F1Mice
    • Rats: F344/N; Mice: B6C3F1; Rats: F344/N
    • Dose: CORE STUDY: R&M: 0,750,1500,3000,4500,6000 PPM/10 PER GROUP; STOP STUDY: R: 0, 1500, 3000, 6000 PPM/30 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Inhalation)  (C62077D) Report Complete 
    • TR-484 (NTIS No. PB2000-105865)  (Peer Review 10/30/1998)
      Toxicology and Carcinogenesis Studies of 2-Butoxyethanol (CAS No. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 31, 62.5, OR 125 PPM M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0719) Completed 
    • Citation: GHANAYEM., B.I., BURKA, L.T., SANDERSM J.M., & METTHEWS, H.B., METABOLISM AND DISPOSITION OF ETHYLENE GLYCOL MONOBUTYL ETHER (2-BUTOXYETHANOL) IN RATS, DRUG METABOLISM & DISPOSITION, VOL 15, #4 478-484, 1987
    • M Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0777) Completed 
    • Citation: SABOURIN, P.J., MEDINSKY, M.A., THURMOND, F., BIRNBAUM, L.S., & HENDERSON, R.F. EFFECT OF DOSE ON THE DISPOSITION OF METHOXYETHANOL, ETHOXYETHANOL AND BUTOXYETHANOL ADMINISTERED DERMALLY TO MALE F344/N RATS. FUNDAMENTAL & APPLIED TOXICOLOGY 19, 124-132 (1992)
    • M Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0778) Completed 
    • Citation: MEDINSKY, M/.A., SINGH, G, BECHTOLD, W.E., BOND, JA.A, SABOURIN, P.J., BIRNBAUM L.S., & HENDERSON, R.F. DISPOSITION OF THREE GLYCOL ETHERS ADMINISTERED IN DRINKING WATER TO MALE F344N/RATS. TOXICOLOGY & APPLIED PHARMACOLOGY, 102, 443-455 (1990)
    • M Rats: F344/N
  • Mechanisms  (S0718) Completed 
    • Citation: GHANAYEM., B.I., SANCHEZ, I.M., MATTHEWS, H.B., DEVELOPMENT OF TOLERANCE TO 2-BUTOXYETHANOL-INDUCED HEMOLYTIC ANEMIA AND STUDIES TO ELUCIDATE THE UNDERLYING MECHANISMS, TOXICOLOGY & APPLIED PHARMACOLOGY 112, 198-206 1992
    • M Rats: F344/N
  • Metabolism (Gavage)  (S0387) Completed 
    • Citation: GHANAYEM, B.I., BLAIR, P.C., THOMPSON, M.B., MARONPOT, R.R. & MATTHEWS, H.B.: EFFECT OF AGE ON THE TOXICITY & METABOLISM OF EGMBE IN RATS, TOXICOL & APPL PHARM, 91:222-234, 1987.
    • M Rats: F344/N
    • Dose: 32, 63, 125, 250 & 500 MG/KG
  • Metabolism (Inhalation)  (S0722) Completed 
    • Citation: SABOURIN, P.J., MEDINSKY, M.A., BIRNBAUM, L.S., GRIFFITH, W.C., & HENDERSON, R.F., EFFECT OF EXPOSURE CONCENTRATION ON THE DISPOSITION OF INHALED BUTOXYETHANOL BY F344 RATS, TOXIOLOGY & APPLIED PHARMACOLOGY 114, 232-238, 1992
    • M Rats: F344/N
  • Other  (S0717) Completed 
    • Citation: GHANAYEM., B.I., METABOLIC AND CELLULAR BASIS OF 2-BUTOXYETHANOL INDUCED HEMOLYTIC ANEMIA IN RATS & ASSESSSMENT OF HUMAN RISK IN VITRO, BIOCHEMICAL PHARMACOLOGY, VOL38., #10, 1679-1684, 1989
    • M Rats: F344/N; Human
  • Other  (S0721) Completed 
    • Citation: GHANAYEM, B.I., WARD, S.M., BLAIR, P.C., MATTHEWS, H.B., COMPARISON OF THE HEMATOLOGIC EFFECTS OF 2-BUTOXYETHANOL USING TWO TYPES OF HEMATOLOGY ANALYZERS, TOXICOLOGY & APPLIED PHARMACOLOGY, 106, 341-345 1990)
    • M Rats: F344/N
  • Toxicokinetic Study  (S0720) Completed 
    • Citation: GHANAYEM., B.I., SANDERS, J.M., CLARK, A.M., BAILER, J., & MATTHEWS, H.B., EFFECTS OF DOSE, AGE, INHIBITION OF METABOLISM AND ELIMINATION ON THE TOXICOKINETCIS OF 2-BUTOXYETHANL AND ITS METABOLITES. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, VOL. 253, NO 1 (1990), PP 136-143
    • M Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (029931) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Micronucleus  (A89412) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A96057) Completed 
    • Rats: F344
    • Male Negative 
  • Salmonella  (006665) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • CONT EXPOS, 120 D MINIMUM Continuous Breeding (Dosed-Water)  (RACB85053) Completed 
    • NTIS No. PB85-226827
      Citation: Ethylene Glycol Monobutyl Ether: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
    • M/F Mice: Swiss
    • Dose: N/A; 0,.5,1.0,2.0%; N/A; N/A
  • 8 CONS D (MTD PHASE), GD 7-14 (REPRO PHASE) Short-Term in vivo Repro. Tox. (Gavage)  (T0076A) Completed 
    • NTIS No. PB84-183540
      Citation: Determination of the Reproductive Effects in Mice of Nine Selected Chemicals
    • F Mice: Swiss
    • Dose: 1180 MG/KG BD WT
  • GD 7-16 Conventional Teratology (Topical Application)  (T0076B) Completed 
    • F Rats: Sprague Dawley
    • Dose: 0.12, 0.35 ML 4 TIMES/DAY
  • GESTATION DAYS 9-11 & 11-13 Conventional Teratology (Gavage)  (TER88076) Completed 
    • NTIS No. PB89-165849
      Citation: Final Report - Teratologic Evaluation of Ethylene Glycol Monobutyl Ether Administered to Fischer-344 Rats on Either Gestational Days 9 through 11 or Days 11 through 13
    • F Rats: F344/N
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: GESTATION DAYS 9-11: 0,30,100, & 200 MG/KG/DAY. GESTATION DAYS 11-13: 0, 30, 100, AND 300 MG/KG/DAY
  • GD 11-13 Conventional Teratology (Gavage)  (TER88141) Completed 
    • NTIS No. PB89-165849
      Citation: Final Report - Teratologic Evaluation of Ethylene Glycol Monobutyl Ether Administered to Fischer-344 Rats on Either Gestational Days 9 through 11 or Days 11 through 13
    • Rats: F344/N
    • Dose: ** 0, 30, 100, 300 PPM

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Web page last updated on January 22, 2009