National Toxicology Program

CASRN: 107-13-1

Formula: C3 H3 N

Synonyms/Common Names:

• AN
• 2-PROPENENITRILE

Known Uses:

CHEM. INTERMEDIATE FOR ANTIOXIDANTS, PHARMACEUTICALS, DYES, SURFACE-ACTIVE AGENTS. MONOMER IN ORGANIC SYNTHESIS. PESTICIDE FUMIGANT FOR GRAIN.

Short-Term Toxicity

• 13-WEEK (Gavage)  (C50215B) Completed 
  • NTIS No. PB2002-102198  (Peer Review 05/03/2001)
    Citation: Toxicology and Carcinogenesis Studies of Acrylonitrile (CAS No. 107-13-1) in B6C3F1 Mice (Gavage Studies)
  • Mice: B6C3F1
  • Dose: MICE: 0, 5, 10, 20, 40, OR 60 MG/KG; 10/SEX/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C50215B) Report Complete 
  • TR-506 (NTIS No. PB2002-102198)  (Peer Review 05/03/2001)
    Toxicology and Carcinogenesis Studies of Acrylonitrile (CAS No. 107-13-1) in B6C3F1 Mice (Gavage Studies)
  • Mice: B6C3F1
  • Carcinogenesis Results
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE

Special Studies

• Absorption Disposition Metabolism Elimination  (S0712) Completed 
  • Citation: BURKA, L.T., SANCHEZ, I.M., AHMED, A.E., GHANAEM, B.I., COMPARATIVE METABOLISM AND DISPOSITIO OF ACRYLONITRILE AND METHACRYLONITRILE IN RATS, ARCH TOXICOL 68: 611-618, 1994
  • M Rats: F344/N
• Other  (S0711) Completed 
  • Citation: FAROOQUI, M.Y.H., MUMTAZ., M.M., GHANAYEM, B.I., & AHMED, A.E., HEMOGLOBIN DEGRADATION LIPID PEROXIDATION, AND INHIBITION OF NA+/K+-ATPASE IN RAT ERYTHROCYTS EXPOSED TO ACRYLONITRILE, JRNL BIOCHEM TOXICOLOGY VOLUEM 5 # 4 221-227 1990
  • M Rats: Sprague Dawley

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (269328) Completed 
  • Citation: Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (701238) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Sex-Linked Recessive Lethal Negative 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (189387) Completed 
  • Citation: Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
  •  Positive 
• Micronucleus  (A56933) Completed 
  • Mice: B6C3F1
  • Female Negative 
• Micronucleus  (A69991) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (A92525) Completed 
  • Mice: B6C3F1
  • Female Negative 
• Salmonella  (198018) Completed 
  • Citation: Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
  •  Positive