Testing Status of Agents at NTP
Theophylline
CASRN: 58-55-9
Formula: C7 H8 N4 O2
Synonyms/Common Names:
- 3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE (9CI)
Known Uses:
DIURETIC, CARDIAC STIMULANT, SMOOTH MUSCLE RELAXANT, ANTIASTHMATIC, OCCURS NATURALLY IN TEA (MERCK 1989)
Short-Term Toxicity
- 14-Day (Gavage)
(C61609A) Completed
- NTIS No. PB99-113342
Citation: Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB99-113342
- 13-Week (Gavage)
(C61609A) Completed
- NTIS No. PB99-113342
Citation: Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,37.5,75,150, M: 0,75,150,300 MG/KG
- NTIS No. PB99-113342
- 13-WEEK (Dosed-Feed)
(C61609B) Completed
- NTIS No. PB99-113342
Citation: Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,1000,2000,4000 PPM
- NTIS No. PB99-113342
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C61609D) Report Complete
- TR-473 (NTIS No. PB99-113342)
(Peer Review 12/11/1996)
Toxicology and Carcinogenesis Studies of Theophylline (CAS No. 58-55-9) in F344/N Rats and B6C3F1 Mice (Feed and Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 7.5, 25, OR 75 MG/KG; 50/GROUP FM: 7.5, 25, OR 75 MG/KG; 50/GROUP MM: 15, 50, OR 150 MG/KG; 50/GROUP
- TR-473 (NTIS No. PB99-113342)
(Peer Review 12/11/1996)
Special Studies
- Absorption Disposition Metabolism Elimination (Intravenous; Gavage)
(S0098) Completed
- M Rats: F344/N; M Rats: F344/N
- Dose: ORAL:25,75 IV:12.5,25 MG/KG
Genetic Toxicology
- Chromosome Aberrations
(356530) Completed
- Citation: McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224
- Citation: McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224
- Mice
- Chromosome Aberation Negative
- In Vitro Cytogenetics (CA/SCE)
(298713) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Micronucleus
(A24621) Completed
- Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
- Mice: B6C3F1
- Male Positive
- Female Negative
- Salmonella
(703371) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative
- Sister Chromatid Exchanges
(356530) Completed
- Citation: McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224
- Citation: McFee, A.F. Chromosomal effects of theophylline measured in mouse marrow cells in vivo. Mutat. Res. Vol. 264 (1991) 219-224
- Mice
- Sister Chromatid Positive (Nonstandard Protocol)
Organ Systems Toxicity
- CONTINUOUS EXPOSURE, 120 DAY MINIMUM Continuous Breeding (Dosed-Feed)
(RACB84074) Completed
- NTIS No. PB85-204659
Citation: Final Report - Theophylline: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drin king Water/Feed - M/F Mice: Swiss
- Dose: N/A; 0,.075,.015,.3%; N/A; N/A
- NTIS No. PB85-204659
- GD 6-15 Conventional Teratology (Dosed-Feed)
(TER84110) Completed
- NTIS No. PB86-108172
Citation: Teratologic Evaluation of Theophylline Administered to CD(R) Rats on Gestational Days 6 through 15 - F Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 0.15%, 0.30%, 0.40%
- NTIS No. PB86-108172
- GD 6-15 Conventional Teratology (Dosed-Water)
(TER84111) Completed
- NTIS No. PB86-103223
Citation: Teratologic Evaluation of Theophylline Administered to CD-1 Mice on Gestational Days 6 through 15 - F Mice: Swiss
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0%, 0.075%, 0.15%, 0.20%
- NTIS No. PB86-103223
Web page last updated on January 22, 2009