National Toxicology Program

CASRN: 62-23-7

Related: P-NITROBENZOYL CHLORIDE (CAS 122-04-3)

Formula: C7 H5 N O4

Synonyms/Common Names:

• BENZOIC ACID, 4-NITRO- (9CI)

Known Uses:

INTERMEDIATE FOR DYE MANUFACTURE

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C61778) Completed 
  • NTIS No. PB95-226254
    Citation: Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CAS No. 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Dosed-Feed)  (C61778) Completed 
  • NTIS No. PB95-226254
    Citation: Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CAS No. 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.062,1.0, M: 0,.125,2.0 %

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C61778B) Report Complete 
  • TR-442 (NTIS No. PB95-226254)  (Peer Review 06/22/1993)
    Toxicology and Carcinogenesis Studies of p-Nitrobenzoic Acid (CAS No. 62-23-7) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats Some Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: 0, 1250, 2500, OR 5000 PPM /60 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (195725) Completed 
  • Citation: Zeiger, E., Shelby, M., Ivett J., and McFee, A. Mutagenicity testing of 5-(4-nitrophenyl)-2, 4-petadien-1-al ("Spy Dust") and its metabolites in vitro and in vivo. Environ. Mutagen. Vol. 9 (1987) 269-280
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Micronucleus  (A44876) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (699655) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Positive 

Organ Systems Toxicity

• > 120 DAYS Continuous Breeding (Dosed-Feed)  (RACB90065) Completed 
  • NTIS No. PB90-253766
    Citation: Final Report on the Reproductive Toxicity of para-Nitrobenzoic Acid in CD-1 Swiss Mice
  • M/F Mice: Swiss
  • Dose: 0,.25,.50,1.0,2.0,3.0; 0,.35,.75,1.5%; 0,.75%; 0,.35,.75,1.5%