Testing Information

Testing Status of Agents at NTP

Phenesterin

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http://ntp.niehs.nih.gov/go/TS-10940-N

CASRN: 3546-10-9

Formula: C39 H59 CL2 N O2

Synonyms/Common Names:

  • CHOLEST-5-EN-3-OL(3BETA)-,4-(BIS(2-CHLOROETHYL)AMINO)BENZENEACETATE (9CI)

Known Uses:

ANTICANCER DRUG

Short-Term Toxicity

  • 14-Day (Gavage)  (C01558) Completed 
    • NTIS No. PB283361  (Peer Review 03/06/1978)
      Citation: Bioassay of Phenesterin for Possible Carcinogenicity (CAS No. 3546-10-9)
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Gavage)  (C01558) Completed 
    • NTIS No. PB283361  (Peer Review 03/06/1978)
      Citation: Bioassay of Phenesterin for Possible Carcinogenicity (CAS No. 3546-10-9)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0,1.0,20, M: 0,1.7,136 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C01558) Report Complete 
    • TR-060 (NTIS No. PB283361)  (Peer Review 03/06/1978)
      Bioassay of Phenesterin for Possible Carcinogenicity (CAS No. 3546-10-9)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,5,10, M: 0,15,30 MG/KG/15 PER GROUP

Genetic Toxicology

  • Drosophila  (422979) Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (012521) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Negative 
  • Salmonella  (461280) Completed 
    •  Negative 
  • Salmonella  (612071) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 

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Web page last updated on January 22, 2009