National Toxicology Program

CASRN: 63-92-3

Formula: C18 H22 CL N O.CL H

Synonyms/Common Names:

• N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)BENZENEMETHANAMINE HYDROCHLORIDE (CI)

Known Uses:

ANTIHYPERTENSIVE AGENT

Short-Term Toxicity

• 14-Day (Intraperitoneal Injection)  (C01661) Completed 
  • NTIS No. PB285095  (Peer Review 03/07/1978)
    Citation: Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity (CAS No. 63-92-3)
  • Rats: Sprague Dawley; Mice: B6C3F1
• 13-Week (Intraperitoneal Injection)  (C01661) Completed 
  • NTIS No. PB285095  (Peer Review 03/07/1978)
    Citation: Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity (CAS No. 63-92-3)
  • Rats: Sprague Dawley; Mice: B6C3F1
  • Dose: R: 0,1.5,30, M: 0,2.5,50 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Intraperitoneal Injection)  (C01661) Report Complete 
  • TR-072 (NTIS No. PB285095)  (Peer Review 03/07/1978)
    Bioassay of Phenoxybenzamine Hydrochloride for Possible Carcinogenicity (CAS No. 63-92-3)
  • Rats: Sprague Dawley; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,5,10, M: 0,12.5,25 MG/KG/35 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (926929) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Salmonella  (695265) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive