National Toxicology Program

CASRN: 961-11-5

Formula: C10 H9 CL4 O4 P

Synonyms/Common Names:

• PHOSPHORIC ACID, 2-CHLORO-1-(2,4,5-TRICHLOROPHENYL)ETHENYL DIMETHYL ESTER (9CI)

Known Uses:

PESTICIDE, CHOLINESTERASE INHIBITOR (MERCK 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00168) Completed 
  • NTIS No. PB278650  (Peer Review 11/28/1977)
    Citation: Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CAS No. 961-11-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00168) Completed 
  • NTIS No. PB278650  (Peer Review 11/28/1977)
    Citation: Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CAS No. 961-11-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,500,8000 (AVG), M: 0,2000,32000 (AVG) PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00168) Report Complete 
  • TR-033 (NTIS No. PB278650)  (Peer Review 11/28/1977)
    Bioassay of Tetrachlorvinphos for Possible Carcinogenicity (CAS No. 961-11-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,4250,8500 (AVG), M: 0,800,1600 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (724074) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Salmonella  (220423) Completed 
  •  Negative