National Toxicology Program

CASRN: 1156-19-0

Formula: C14 H21 N3 O3 S

Synonyms/Common Names:

• N-(((HEXAHYDRO-1H-AZEPIN-1-YL)AMINO)CARBONYL)-4-METHYL-BENZENESULFONAMIDE (9CI)

Known Uses:

HYPOGLYCEMIC AGENT

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03327) Completed 
  • NTIS No. PB284610  (Peer Review 03/06/1978)
    Citation: Bioassay of Tolazamide for Possible Carcinogenicity (CAS No. 1156-19-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03327) Completed 
  • NTIS No. PB284610  (Peer Review 03/06/1978)
    Citation: Bioassay of Tolazamide for Possible Carcinogenicity (CAS No. 1156-19-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: FR: 0,2500,40000, FM: 0,2000,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03327) Report Complete 
  • TR-051 (NTIS No. PB284610)  (Peer Review 03/06/1978)
    Bioassay of Tolazamide for Possible Carcinogenicity (CAS No. 1156-19-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,5000,10000 PPM/35 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (225955) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (255587) Completed 
  •  Negative 
• Salmonella  (352518) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Inconclusive