Testing Status of Agents at NTP
Tolbutamide
CASRN: 64-77-7
Formula: C12 H18 N2 O3 S
Synonyms/Common Names:
- N-((BUTYLAMINO)CARBONYL)-4-METHYLBENZENESULFONAMIDE (9CI)
Known Uses:
HYPOGLYCEMIC
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01763) Completed
- NTIS No. PB274483
(Peer Review 09/26/1977)
Citation: Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB274483
(Peer Review 09/26/1977)
- 13-Week (Dosed-Feed)
(C01763) Completed
- NTIS No. PB274483
(Peer Review 09/26/1977)
Citation: Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7) - Rats: F344/N; Mice: B6C3F1
- Dose: MR: 0,300,6000, FR: 0,12000,24000, MM: 0,500,10000, FM: 0,20000,40000 PPM/5 PER GROUP
- NTIS No. PB274483
(Peer Review 09/26/1977)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01763) Report Complete
- TR-031 (NTIS No. PB274483)
(Peer Review 09/26/1977)
Bioassay of Tolbutamide for Possible Carcinogenicity (CAS No. 64-77-7) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,12000,24000, M: 0,25000,50000 PPM/35 PER GROUP
- TR-031 (NTIS No. PB274483)
(Peer Review 09/26/1977)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(481185) Completed
- Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(465250) Completed
- Negative
- Salmonella
(736579) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Web page last updated on January 22, 2009