Testing Information

Testing Status of Agents at NTP

4,4'-Sulfonyldianiline (Dapsone)

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http://ntp.niehs.nih.gov/go/TS-10890-X

CASRN: 80-08-0

Formula: C12 H12 N2 O2 S

Synonyms/Common Names:

  • DAPSONE
  • DAPSONE (AIDS)
  • 4,4'-SULFONYBISBENZENAMINE (9CI)

Known Uses:

HARDENING AGENT FOR EPOXY RESINS; TOPICAL ANTIBACTERIAL AGENT; TREATMENT OF GYNECOLOGIC NEOPLASMS; ANTIBACTERIAL/ANTIPROTOZOAL IN VET. MEDICINE, USED IN TREATMENT OF LEPROSY

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01718) Completed 
    • NTIS No. PB274394  (Peer Review 07/25/1977)
      Citation: Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01718) Completed 
    • NTIS No. PB274394  (Peer Review 07/25/1977)
      Citation: Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,1200,30000, M: 0,2000,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01718) Report Complete 
    • TR-020 (NTIS No. PB274394)  (Peer Review 07/25/1977)
      Bioassay of Dapsone for Possible Carcinogenicity (CAS No. 80-08-0)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,600,1200, M: 0,500,1000 PPM/35 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (954704) Completed 
    • Chromosome Aberation Weakly Positive 
    • Sister Chromatid Exchange Negative 
  • In Vitro Cytogenetics (CA/SCE)  (962654) Completed 
    • Chromosome Aberation Weakly Positive 
    • Sister Chromatid Exchange Not Tested 
  • Mouse Lymphoma  (001410) Completed 
    • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
    •  Negative 
  • Salmonella (NCI)  (CV-204) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Negative 
  • Salmonella  (318705) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90015) Completed 
    • NTIS No. PB92-140383
      Citation: Summary Reports on Immunotoxicology Vol. 1, No. 1-15
    • Citation: SUMMARY (1-15)
    • F Mice: C57BL/6
    • Dose: 0, 3.4, 13.5, 54.0 MG/KG
  • 1 TO 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93157) Completed 
    • M/F Mice: Swiss
    • Dose: N/A; N/A; N/A; N/A

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Web page last updated on January 22, 2009