National Toxicology Program

CASRN: 1937-37-7

Formula: C34-H27-N9-O7-S2.2NA

Synonyms/Common Names:

• 4-AMINO-3-((4'-((2,4-DIAMINOPHENYL)AZO)(1,1'-BIPHENYL)-4-YL)AZO)-5-HYDROXY-6-(PHENYLAZO)-2,7-NAPHTHALENEDISULFONIC ACIDDISODIUM SALT (9CI)
• BLACK 38, C.I. ACID

Known Uses:

DYE FOR TEXTILES, LEATHER, INK; BIOLOGICAL AND WOOD STAINS; HAIR DYES (FORMERLY USED)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C54557) Completed 
  • NTIS No. PB280204  (Peer Review 03/06/1978)
    Citation: 13-Week Subchronic Toxicity Studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 Dyes
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,190,375,750,1500,3000, M: 0,750,1500,3000,6000,12500 PPM/10 PER GROUP
• 13-Week (Dosed-Feed)  (C54557) Report Complete 
  • NTIS No. PB280204  (Peer Review 03/06/1978)
    Citation: 13-Week Subchronic Toxicity Studies of Direct Blue 6, Direct Black 38, and Direct Brown 95 Dyes
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,190,375,750,1500,3000, M: 0,750,1500,3000,6000,12500 PPM/10 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (325575) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (604832) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive 
• Salmonella  (921044) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive 
• Salmonella Reduction  (915213) Completed 
  • Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
  •  Positive 

Organ Systems Toxicity

• GD 6-15 Conventional Teratology (Subcutaneous Injection)  (T0121) Completed 
  • F Mice: Swiss
  • Dose: 0, 100, 150, 200, 300, 400 MG/KG/DAY