Testing Status of Agents at NTP
Hydrazobenzene
CASRN: 122-66-7
Formula: C12-H12-N2
Synonyms/Common Names:
- 1,2-DIPHENYLHYDRAZINE (9CI)
Known Uses:
PRECURSOR FOR DYES; PREPARATION OF PHENYLBUTAZONE
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C01854) Completed
- NTIS No. PB285791
(Peer Review 04/26/1978)
Citation: Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB285791
(Peer Review 04/26/1978)
- 13-Week (Dosed-Feed)
(C01854) Completed
- NTIS No. PB285791
(Peer Review 04/26/1978)
Citation: Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,.007,.423 %/5 PER GROUP
- NTIS No. PB285791
(Peer Review 04/26/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C01854) Report Complete
- TR-092 (NTIS No. PB285791)
(Peer Review 04/26/1978)
Bioassay of Hydrazobenzene for Possible Carcinogenicity (CAS No. 122-66-7) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Positive
- Female Rats Positive
- Male Mice Negative
- Female Mice Positive
- Dose: MR: 0,.008,.03 (AVG), FR: 0,.004,.01 (AVG), MM: 0,.008,.04 (AVG), FM: 0,.004,.04 (AVG) %/50 PER GROUP
- TR-092 (NTIS No. PB285791)
(Peer Review 04/26/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(522990) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(520041) Completed
- Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Salmonella (NCI)
(CV-355) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
- Salmonella-NCI Positive
- Salmonella
(519790) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Positive
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