National Toxicology Program

CASRN: 303-34-4

Formula: C21-H33-N-O7

Synonyms/Common Names:

• 7-((2,3-DIHYDROXY-2-(1-METHOXYETHYL)-3-METHYL-1-OXOBUTOXY)METHYL)-2-BUTANOIC ACID (9CI)

Known Uses:

CARCINOGEN IN RESEARCH, USE IN INDIA TO TREAT SNAKEBITES, AS AN EMETIC, HEPATOTOXIC PYRROLIZIDINE (MERCK 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C01478) Completed 
  • NTIS No. PB278641  (Peer Review 11/28/1978)
    Citation: Bioassay of Lasiocarpine for Possible Carcinogenicity (CAS No. 303-34-4)
  • Rats: F344/N
• 13-Week (Dosed-Feed)  (C01478) Completed 
  • NTIS No. PB278641  (Peer Review 11/28/1978)
    Citation: Bioassay of Lasiocarpine for Possible Carcinogenicity (CAS No. 303-34-4)
  • Rats: F344/N
  • Dose: 0,5,160 PPM/30 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C01478) Report Complete 
  • TR-039 (NTIS No. PB278641)  (Peer Review 11/28/1978)
    Bioassay of Lasiocarpine for Possible Carcinogenicity (CAS No. 303-34-4)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Dose: 0,7,15,30 PPM/48 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (256879) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (005545) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Positive 
• Micronucleus  (A44011) Completed 
  • Female Positive 
• Salmonella  (270072) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive