Testing Status of Agents at NTP
Methoxychlor
CASRN: 72-43-5
Related: KID PEST PROJECT (METHOXYCHLOR)
Formula: C16-H15-CL3-O2
Synonyms/Common Names:
- 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS(4-METHOXYBENZENE) (9CI)
Known Uses:
INSECTICIDE
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C00497) Completed
- NTIS No. PB278271
(Peer Review 11/18/1977)
Citation: Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5) - Rats: Osborne Mendel; Mice: B6C3F1
- NTIS No. PB278271
(Peer Review 11/18/1977)
- 13-Week (Dosed-Feed)
(C00497) Completed
- NTIS No. PB278271
(Peer Review 11/18/1977)
Citation: Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5) - Rats: Osborne Mendel; Mice: B6C3F1
- Dose: R: 0,316,3160, M: 0,1000,10000 PPM/5 PER GROUP
- NTIS No. PB278271
(Peer Review 11/18/1977)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C00497) Report Complete
- TR-035 (NTIS No. PB278271)
(Peer Review 11/18/1977)
Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5) - Rats: Osborne Mendel; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: MR: 0,448,845 (AVG), FR: 0,750,1385 (AVG), MM: 0,1746,3491 (AVG), FM: 0,997,1994 (AVG) PPM/50 PER GROUP
- TR-035 (NTIS No. PB278271)
(Peer Review 11/18/1977)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(344617) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Positive
- In Vitro Cytogenetics (CA/SCE)
(639870) Completed
- Chromosome Aberation Negative
- Sister Chromatid Exchange Not Tested
- Mouse Lymphoma (NCI)
(G16413) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G84704) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Salmonella (NCI)
(N-9092) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
- Salmonella-NCI Negative
- Salmonella
(391422) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Negative
- Salmonella
(684566) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Negative
Web page last updated on January 22, 2009