National Toxicology Program

CASRN: 101-54-2

Formula: C12-H12-N2

Synonyms/Common Names:

• N-PHENYL-1,4-BENZENEDIAMINE (9CI)

Known Uses:

INDUSTRIAL INTERMEDIATE, HAIR DYES.

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02233) Completed 
  • NTIS No. PB285856  (Peer Review 03/06/1978)
    Citation: Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CAS No. 101-54-2)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02233) Completed 
  • NTIS No. PB285856  (Peer Review 03/06/1978)
    Citation: Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CAS No. 101-54-2)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,2200,10000, M: 0,3000,31500 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02233) Report Complete 
  • TR-082 (NTIS No. PB285856)  (Peer Review 03/06/1978)
    Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CAS No. 101-54-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,600,1200, MM: 0,2057,4114 (AVG), FM: 0,3672,8170 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (887002) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (867606) Completed 
  •  Positive 
• Salmonella  (231064) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative