Testing Information

Testing Status of Agents at NTP

Ampicillin trihydrate

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10832-H

CASRN: 7177-48-2

Related: AMPICILLIN 69-53-4

Formula: C16 H19 N3 O4 S.3H2 O

Synonyms/Common Names:

  • AMINOBENZYLPENICILLIN TRIHYDRATE (9CI)

Known Uses:

ANTIBIOTIC, ANTIMICROBIAL

Short-Term Toxicity

  • 14-Day (Gavage)  (C56086) Completed 
    • NTIS No. PB87-204160  (Peer Review 12/09/1985)
      Citation: Toxicology and Carcinogenesis Studies of Ampicillin Trihydrate (CAS No. 7177-48-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C56086) Completed 
    • NTIS No. PB87-204160  (Peer Review 12/09/1985)
      Citation: Toxicology and Carcinogenesis Studies of Ampicillin Trihydrate (CAS No. 7177-48-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,180,3000, M: 0,250,3000 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C56086) Report Complete 
    • TR-318 (NTIS No. PB87-204160)  (Peer Review 12/09/1985)
      Toxicology and Carcinogenesis Studies of Ampicillin Trihydrate (CAS No. 7177-48-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0,750,1500, M: 0,1500,3000 MG/KG/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (600069) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (351941) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Negative 
  • Salmonella  (730053) Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Back to top

Web page last updated on January 22, 2009