National Toxicology Program

CASRN: 106-92-3

Formula: C6 H10 O2

Synonyms/Common Names:

• ((2-PROPENYLOXY)METHYL)-OXIRANE (9CI)

Known Uses:

STABILIZER OF CHLORINATED COMPOUNDS, VINYL RESINS, RUBBER; RESIN INTERMEDIATE.

Short-Term Toxicity

• 14-Day (Inhalation)  (C56666) Completed 
  • NTIS No. PB90-260027  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Inhalation)  (C56666) Completed 
  • NTIS No. PB90-260027  (Peer Review 06/27/1989)
    Citation: Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,4,200, M: 0,1,30 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C56666) Report Complete 
  • TR-376 (NTIS No. PB90-260027)  (Peer Review 06/27/1989)
    Toxicology and Carcinogenesis Studies of Allyl Glycidyl Ether (CAS No. 106-92-3) in Osborne-Mendel Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal Evidence 
  • Female Rats No Evidence 
  • Male Mice Some Evidence 
  • Female Mice Equivocal Evidence 
  • Dose: R&M: 0,5,10 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (691488) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (486088) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Micronucleus  (446759) Completed 
  • Mice: B6C3F1
  • Male Positive 
• Micronucleus  (A65776) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (838866) Completed 
  • Citation: Canter, D.A., Zeiger, E., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Comparative mutagenicity of aliphatic epoxides in Salmonella Mutation Res. Vol. 172 (1986) 105-138
  •  Positive