National Toxicology Program

CASRN: 11097-69-1

Formula: C12-H9-CL

Synonyms/Common Names:

• CHLORINATED BIPHENYL

Known Uses:

PESTICIDE

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C02664) Completed 
  • NTIS No. PB279624  (Peer Review 11/28/1977)
    Citation: Bioassay of Aroclor® for Possible Carcinogenicity (CAS No. 27323-18-8)
  • Rats: F344/N
• 13-WEEK (Dosed-Feed)  (C02664) Completed 
  • NTIS No. PB279624  (Peer Review 11/28/1977)
    Citation: Bioassay of Aroclor® for Possible Carcinogenicity (CAS No. 27323-18-8)
  • Rats: F344/N
  • Dose: 0,25,400 PPM/15 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02664) Report Complete 
  • TR-038 (NTIS No. PB279624)  (Peer Review 11/28/1977)
    Bioassay of Aroclor® for Possible Carcinogenicity (CAS No. 27323-18-8)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Equivocal 
  • Dose: 0,25,50,100 PPM/24 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (166234) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (207552) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (783442) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Weakly Positive 
• Micronucleus  (166234) Completed 
  • Mice: B6C3F1
  • Male Not Tested 
• Micronucleus  (973822) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella (NCI)  (N-9140) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (101496) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative