National Toxicology Program

CASRN: 61702-44-1

Formula: C6-H7-CL-N2.H2-O4-S

Synonyms/Common Names:

• 2-CHLORO-1,4-BENZENEDIAMINE SULFATE(1:1) (9CI)

Known Uses:

HAIR DYES

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03316) Completed 
  • NTIS No. PB286370  (Peer Review 04/26/1978)
    Citation: Bioassay of 2-Chloro-p-phenylenediamine Sulfate for Possible Carcinogenicity (CAS No. 61702-44-1)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03316) Completed 
  • NTIS No. PB286370  (Peer Review 04/26/1978)
    Citation: Bioassay of 2-Chloro-p-phenylenediamine Sulfate for Possible Carcinogenicity (CAS No. 61702-44-1)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,.03,3.0 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03316) Report Complete 
  • TR-113 (NTIS No. PB286370)  (Peer Review 04/26/1978)
    Bioassay of 2-Chloro-p-phenylenediamine Sulfate for Possible Carcinogenicity (CAS No. 61702-44-1)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,.15,.30, M: 0,.3,.6 %DIET/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (110183) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (962361) Completed 
  •  Positive 
• Salmonella  (832540) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive