Testing Status of Agents at NTP
2,4-Dimethoxyaniline hydrochloride
CASRN: 54150-69-5
Related: 2,4-DIMETHOXYANILINE (CAS 2735-04-8)
Formula: C8 H11 N O2.H CL
Synonyms/Common Names:
- 2,4-DIMETHOXYBENZENAMINE HYDROCHLORIDE (9CI)
Known Uses:
SALT OF 2,4-DIMETHOXYANILINE; DYE INTERMEDIATE; NOT USED COMMERCIALLY
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C02255) Completed
- NTIS No. PB288625
(Peer Review 08/31/1978)
Citation: Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB288625
(Peer Review 08/31/1978)
- 13-Week (Dosed-Feed)
(C02255) Completed
- NTIS No. PB288625
(Peer Review 08/31/1978)
Citation: Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,2150,21600, M: 0,3160,31500 PPM/5 PER GROUP
- NTIS No. PB288625
(Peer Review 08/31/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C02255) Report Complete
- TR-171 (NTIS No. PB288625)
(Peer Review 08/31/1978)
Bioassay of 2,4-Dimethoxyaniline Hydrochloride for Possible Carcinogenicity (CAS No. 54150-69-5) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,1500,3000, M: 0,2500,5000 PPM/50 PER GROUP
- TR-171 (NTIS No. PB288625)
(Peer Review 08/31/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(434745) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Mouse Lymphoma
(832423) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Positive
- Micronucleus
(756856) Completed
- Mice: B6C3F1
- Male Negative
- Salmonella (NCI)
(N-9379) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(792648) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
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