National Toxicology Program

CASRN: 57653-85-7

Formula: C12 H2 CL6 O2

Synonyms/Common Names:

• 1,2,3,6,7,8-HEXACHLORODIBENZO(B,E)(1,4)DIOXIN (9CI)

Known Uses:

NOT USED COMMERCIALLY IN THE U.S. CONTAMINANT OF HERBICIDES

Short-Term Toxicity

• 14-Day (Gavage)  (C03703A) Completed 
  • NTIS No. PB81-124844  (Peer Review 02/15/1980)
    Citation: Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CAS No. 57653-85-7,CAS No. 19408-74-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 14-Day (Topical Application)  (C03703B) Completed 
  • NTIS No. PB81-124836  (Peer Review 02/15/1980)
    Citation: Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CAS No. 57653-85-7; CAS No. 19408-74-3)
  • Mice: Swiss Webster
• 13-Week (Gavage)  (C03703A) Completed 
  • NTIS No. PB81-124844  (Peer Review 02/15/1980)
    Citation: Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CAS No. 57653-85-7,CAS No. 19408-74-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,2.5,100, M: 0,1.25,50 UG/KG/10 PER GROUP
• 13-Week (Topical Application)  (C03703B) Completed 
  • NTIS No. PB81-124836  (Peer Review 02/15/1980)
    Citation: Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CAS No. 57653-85-7; CAS No. 19408-74-3)
  • Mice: Swiss Webster
  • Dose: 0,.01,50 UG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C03703A) Report Complete 
  • TR-198 (NTIS No. PB81-124844)  (Peer Review 02/15/1980)
    Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Gavage) for Possible Carcinogenicity (CAS No. 57653-85-7,CAS No. 19408-74-3)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R&MM: 0,1.25,2.5,5.0, FM: 0,2.5,5.0,10.0 UG/KG/50 PER GROUP
• 2-Year (Topical Application)  (C03703B) Report Complete 
  • TR-202 (NTIS No. PB81-124836)  (Peer Review 02/15/1980)
    Bioassay of a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (Dermal Study) for Possible Carcinogenicity (CAS No. 57653-85-7; CAS No. 19408-74-3)
  • Mice: Swiss Webster
  • Carcinogenesis Results
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,.005,.01 UG/60 PER GROUP

Organ Systems Toxicity

• 14 DAYS Immunotoxicity (Gavage)  (IMM84001) Completed 
  • F Mice: B6C3F1
  • Dose: 0, 0.056, 0.56 OR 5.6 UG/KG HCDD AND 0.86 UG/KG TCDD