National Toxicology Program

CASRN: 21739-91-3

Formula: C11-H9-BR-O4.NA

Synonyms/Common Names:

• 3-BROMO-4-(4-METHOXYPHENYL)-4-OXO-2-BUTENOIC ACID SODIUM SALT (9CI)

Known Uses:

CYTOSTATIC AGENT (FORMERLY)

Short-Term Toxicity

• 13-Week (Intraperitoneal Injection)  (C50737) Completed 
  • NTIS No. PB82-163312  (Peer Review 06/27/1980)
    Citation: Carcinogenesis Bioassay of Cytembena (CAS No. 21739-91-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,1.8,29, M: 0,3.0,48 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Intraperitoneal Injection)  (C50737) Report Complete 
  • TR-207 (NTIS No. PB82-163312)  (Peer Review 06/27/1980)
    Carcinogenesis Bioassay of Cytembena (CAS No. 21739-91-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,7,14, M: 0,12,24 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (483291) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (404197) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (861418) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (644192) Completed 
  • Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
  •  Positive 
• Micronucleus  (983684) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (379904) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (483291) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)