National Toxicology Program

CASRN: 20265-97-8

Related: TRANSGENIC MODEL EVALUATION (P-ANISIDINE HCL)

Formula: C7 H9 N O.CL H

Synonyms/Common Names:

• 4-METHOXYBENZENEAMINE HYDROCHLORIDE (9CI)

Known Uses:

MANUFACTURE OF AZO DYES

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C03758) Completed 
  • NTIS No. PB286951  (Peer Review 04/26/1978)
    Citation: Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 20265-97-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C03758) Completed 
  • NTIS No. PB286951  (Peer Review 04/26/1978)
    Citation: Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 20265-97-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.1,3.0 %/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C03758) Report Complete 
  • TR-116 (NTIS No. PB286951)  (Peer Review 04/26/1978)
    Bioassay of p-Anisidine Hydrochloride for Possible Carcinogenicity (CAS No. 20265-97-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,.3,.6, M: 0,.5,1.0 %/55 PER GROUP

Genetic Toxicology

• Mouse Lymphoma  (802685) Completed 
  •  Positive 
• Salmonella (NCI)  (N-9339) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive