National Toxicology Program

CASRN: 19010-66-3

Formula: C6-H12-N2-Pb-S4

Synonyms/Common Names:

• BIS(DIMETHYLCARBAMODITHIOATO-S,S')-LEAD,(T-4) (9CI)

Known Uses:

VULCANIZATION

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C02891) Completed 
  • NTIS No. PB298512  (Peer Review 12/13/1978)
    Citation: Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CAS No. 19010-66-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,62,500, M: 0,62,250 PPM/51 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02891) Report Complete 
  • TR-151 (NTIS No. PB298512)  (Peer Review 12/13/1978)
    Bioassay of Lead Dimethyldithiocarbamate for Possible Carcinogenicity (CAS No. 19010-66-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,25,50 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (615571) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• In Vitro Cytogenetics (CA/SCE)  (962975) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Not Tested 
• Drosophila  (259202) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Salmonella  (247220) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive