National Toxicology Program

CASRN: 15481-70-6

Related: TRANSGENIC MODEL EVALUATION (2,6-DIAMINOTOLUENE HCL)

Formula: C7 H10 N2.2HCL

Synonyms/Common Names:

• 1,3-BENZENEDIAMINE, 2-METHYL-, DIHYDROCHLORIDE (9CI)
• 2,6-DIAMINOTOLUENE DIHYDROCHLORIDE

Known Uses:

INTERMEDIATE FOR DYES, POLYURETHANE FOAMS, AND ELASTOMERS; FEED

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50317) Completed 
  • NTIS No. PB80-217912  (Peer Review 02/15/1980)
    Citation: Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CAS No. 15481-70-6)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50317) Completed 
  • NTIS No. PB80-217912  (Peer Review 02/15/1980)
    Citation: Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CAS No. 15481-70-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,100,1000, M: 0,10,1000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50317) Report Complete 
  • TR-200 (NTIS No. PB80-217912)  (Peer Review 02/15/1980)
    Bioassay of 2,6-Toluenediamine Dihydrochloride for Possible Carcinogenicity (CAS No. 15481-70-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,250,500, M: 0,50,100 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (051468) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Chromosome Aberation  Negative 
• Chromosome Aberrations  (337746) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (717361) Completed 
  • Citation: Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (774876) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (612221) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Micronucleus  (256727) Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Micronucleus  (889785) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Positive 
• Salmonella  (982821) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (051468) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Sister Chromatid  Negative 
• Sister Chromatid Exchanges  (337746) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

• Total Reproductive Capacity  (TRC98048) Completed 
  • F Mice