National Toxicology Program

CASRN: 13171-21-6

Formula: C10-H19-CL-N-O5-P

Synonyms/Common Names:

• PHOSPHORIC ACID,2-CHLORO-3-(DIETHYLAMINO)-1-METHYL-3-OXO-1-PROPENYL DIMETHYL ESTER (9CI)

Known Uses:

PESTICIDE, CHOLINESTERASE INHIBITOR (MERCK 1989)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00588) Completed 
  • NTIS No. PB288800  (Peer Review 07/25/1977)
    Citation: Bioassay of Phosphamidon for Possible Carcinogenicity (CAS No. 13171-21-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00588) Completed 
  • NTIS No. PB288800  (Peer Review 07/25/1977)
    Citation: Bioassay of Phosphamidon for Possible Carcinogenicity (CAS No. 13171-21-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: 0,10,1280 (AVG) PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00588) Report Complete 
  • TR-016 (NTIS No. PB288800)  (Peer Review 07/25/1977)
    Bioassay of Phosphamidon for Possible Carcinogenicity (CAS No. 13171-21-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Equivocal 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,80,160 PPM/50 PER GROUP

Genetic Toxicology

• Salmonella  (607160) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive