National Toxicology Program

CASRN: 12001-29-5

Formula: H4 MG3 O9 SI2

Known Uses:

ASBESTOS, CHRYSOTILE: ASBESTOS CEMENT. TEXTILES. INSULATION. FRICTION PRODUCTS. FIREPROOFING AGENT. (TDB)

Nomination Background

Short-Term Toxicity

• 13-Week (Dosed-Feed)  (C61234A) Completed 
  • NTIS No. PB86-167103  (Peer Review 07/27/1984)
    Citation: Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N
• 13-Week (Dosed-Feed)  (C61234B) Completed 
  • NTIS No. PB91-142380  (Peer Review 06/23/1981)
    Citation: Lifetime Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in Syrian Golden Hamsters (Feed Studies)
  • Hamsters: Syrian Golden
• 13-Week (Dosed-Feed)  (C61234E) Completed 
  • NTIS No. PB86-167103  (Peer Review 07/27/1984)
    Citation: Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C61234A) Report Complete 
  • TR-295 (NTIS No. PB86-167103)  (Peer Review 07/27/1984)
    Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats No Evidence 
  • Dose: 0,1 %/250 PER GROUP
• 2-Year (Dosed-Feed)  (C61234B) Report Complete 
  • TR-246 (NTIS No. PB91-142380)  (Peer Review 06/23/1981)
    Lifetime Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in Syrian Golden Hamsters (Feed Studies)
  • Hamsters: Syrian Golden
  • Carcinogenesis Results
  • Male Hamsters Negative 
  • Female Hamsters Negative 
  • Dose: 0,1 %/60 PER GROUP
• 2-Year (Dosed-Feed)  (C61234E) Report Complete 
  • TR-295 (NTIS No. PB86-167103)  (Peer Review 07/27/1984)
    Toxicology and Carcinogenesis Studies of Chrysotile Asbestos (CAS No. 12001-29-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N
  • Dose: 0,1% /250 PER GROUP