National Toxicology Program

CASRN: 9000-40-2

Formula: N/F

Synonyms/Common Names:

• CAROB GUM (9CI)

Known Uses:

STABILIZER, THICKENER, BINDER IN FOODS & COSMETICS, PHARMACEUTIC AGENT, IN PAINTS, IN TX OF DIARRHEA (MERCK)

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C50419) Completed 
  • NTIS No. PB82-163320  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of Locust Bean Gum (CAS No. 9000-40-2) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C50419) Completed 
  • NTIS No. PB82-163320  (Peer Review 10/15/1980)
    Citation: Carcinogenesis Bioassay of Locust Bean Gum (CAS No. 9000-40-2) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6300,100000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C50419) Report Complete 
  • TR-221 (NTIS No. PB82-163320)  (Peer Review 10/15/1980)
    Carcinogenesis Bioassay of Locust Bean Gum (CAS No. 9000-40-2) in F344 Rats and B6C3F1 Mice (Feed Study)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,25000,50000 PPM/50 PER GROUP

Genetic Toxicology

• Salmonella  (945885) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Negative