National Toxicology Program

CASRN: 7446-34-6

Related: SELSUN

Formula: S2 SE

Synonyms/Common Names:

• SELENIUM DISULFIDE

Known Uses:

ANTIDANDRUFF SHAMPOO, GLASS, ELECTRONICS, RUBBER, IN TREATMENT OF FUNGAL INFECTIONS OF SKIN (HSDB 1990)

Short-Term Toxicity

• 14-Day (Gavage)  (C50033A) Completed 
  • NTIS No. PB82-164955  (Peer Review 05/01/1979)
    Citation: Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Rats: F344/N; Mice: B6C3F1
• 2-WEEK (Topical Application)  (C50033B) Completed 
  • NTIS No. PB82-165291  (Peer Review 05/01/1979)
    Citation: Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Mice: Swiss
• 13-Week (Gavage)  (C50033A) Completed 
  • NTIS No. PB82-164955  (Peer Review 05/01/1979)
    Citation: Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,3.2,31.6, M: 0,21.6,464 MG/KG/10 PER GROUP
• 13-WEEK (Topical Application)  (C50033B) Completed 
  • NTIS No. PB82-165291  (Peer Review 05/01/1979)
    Citation: Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Mice: Swiss
  • Dose: 0,1.0,50 MG/DAY/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C50033A) Report Complete 
  • TR-194 (NTIS No. PB82-164955)  (Peer Review 05/01/1979)
    Bioassay of Selenium Sulfide (Gavage) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Positive 
  • Dose: R: 0,3,15, M: 0,20,100 PPM/50 PER GROUP
• 2-YEAR (Topical Application)  (C50033B) Report Complete 
  • TR-197 (NTIS No. PB82-165291)  (Peer Review 05/01/1979)
    Bioassay of Selenium Sulfide (Dermal Study) for Possible Carcinogenicity (CAS No. 7446-34-6)
  • Mice: Swiss
  • Carcinogenesis Results
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,0.5,1.0 MG/DAY/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (023793) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Chromosome Aberation  Positive 
• Chromosome Aberrations  (A25043) Completed 
  • Mice
  • Chromosome Aberation  Positive (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (807686) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (610185) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (124703) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Micronucleus  (505251) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A25043) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (029359) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Sister Chromatid Exchanges  (023793) Completed 
  • Citation: Shelby, M.D. and Witt, K.L. Comparision of Results from Mouse Bone Marrow Chromosome Aberration and Micronucleus Test 25 (1995) Vol. 25, 1995 302-313
  • Mice
  • Sister Chromatid  Positive