National Toxicology Program

CASRN: 120-40-1

Formula: C16-H33-N-O3

Synonyms/Common Names:

• DODECANAMIDE, N,N-BIS(2-HYDROXYETHYL)- (8CI) (9CI)

Known Uses:

FOAM STABILIZER FOR LIQUID HOUSEHOLD DETERGENTS AND SHAMPOOS. (TDB)

Short-Term Toxicity

• 13-WEEK (Topical Application)  (C55323B) Completed 
  • NTIS No. PB99-169989  (Peer Review 12/10/1997)
    Citation: Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS No. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 25, 50, 100, 200, OR 400 MG/KG; 20/SEX/GROUP M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP

Long-Term Carcinogenicity

• 2-YEAR (Topical Application)  (C55323B) Report Complete 
  • TR-480 (NTIS No. PB99-169989)  (Peer Review 12/10/1997)
    Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS No. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice Some Evidence 
  • Dose: R: 0, 50, OR 100 MG/KG M: 0, 100, OR 200 MG/KG (50/SEX/SPECIES/GROUP)

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage; Topical Application)  (S0611) Completed 
  • Citation: MATHEWS, J.M., DECOSTA, K AND THOMAS, B.F., LAURAMIDE DIETHANOLAMINE ABSORPTION, METABOLISM & DISPOSITION IN RATS & MICE AFTER ORAL, IV & DERMAL ADMIN, DRUG MET & DISPOSITION 24(7):702, 1996
  • M Rats: F344/N; M Mice: B6C3F1; M Rats: F344/N; M Rats: F344/N; M Mice: B6C3F1
  • Dose: gav: rats: 1000 mg/kg, sp: rats: 25 and 400 mg/kg, mice: 50, 100, 200, and 800 mg/kg, iv: rats: 25 mg/kg, mice: 50 mg/kg

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (836554) Completed 
  • Citation: Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (920902) Completed 
  •  Negative 
• Micronucleus  (A82445) Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (854154) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative