National Toxicology Program

CASRN: 6959-47-3

Related: 3-CHLOROMETHYLPYRIDINE HYDROCHLORIDE (CAS 6959-48-4)

Formula: C6-H6-Cl-N.Cl-H

Known Uses:

INTERMEDIATE FOR SUNSCREENS, ANALGESICS AND ANTI-INFLAMMATORY AGENTS

Short-Term Toxicity

• 14-Day (Gavage)  (C03907) Completed 
  • NTIS No. PB295895  (Peer Review 06/29/1978)
    Citation: Bioassay of 2-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-47-3)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C03907) Completed 
  • NTIS No. PB295895  (Peer Review 06/29/1978)
    Citation: Bioassay of 2-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-47-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,68,316, M: 0,100,464 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C03907) Report Complete 
  • TR-178 (NTIS No. PB295895)  (Peer Review 06/29/1978)
    Bioassay of 2-(Chloromethyl)pyridine Hydrochloride for Possible Carcinogenicity (CAS No. 6959-47-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,75,150, M: 0,125,250 MG/KG/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (145263) Completed 
  • Mice
  • Chromosome Aberation  Negative (Nonstandard Protocol) 
• In Vitro Cytogenetics (CA/SCE)  (448657) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (064670) Completed 
  • Citation: Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila. VIII. Reexamination of equivocal results. Environ. Molec. Mutagen. Vol. 19 (1992) 227-234
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Drosophila  (082163) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (465584) Completed 
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (783983) Completed 
  • Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (861777) Completed 
  •  Positive 
• Micronucleus  (A65556) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (374887) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive 
• Sister Chromatid Exchanges  (145263) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)