Testing Status of Agents at NTP
C.I. Acid orange 3
CASRN: 6373-74-6
Formula: C18-H14-N4-O7-S.NA
Synonyms/Common Names:
- 5-((2,4-DINITROPHENYL)AMINO)-2-(PHENYLAMINO)-BENZENESULFONIC ACID MONOSODIUM SALT (9CI)
- ORANGE 3, C.I. ACID
Known Uses:
DYEING ACETATE, WOOL, NYLON, SILK, AND LEATHER; SHADING COMPONENT IN SOAPS AND WOOD STAINS. A DINITRODIPHENYLAMINE DERIVATIVE USED IN SEMIPERMANENT HAIR COLORING PRODUCTS.
Short-Term Toxicity
- 14-Day (Gavage)
(C54911) Completed
- NTIS No. PB89-216550
(Peer Review 07/14/1987)
Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB89-216550
(Peer Review 07/14/1987)
- 13-Week (Gavage)
(C54911) Completed
- NTIS No. PB89-216550
(Peer Review 07/14/1987)
Citation: Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,94,1500, M: 0,250,2000 MG/KG/10 PER GROUP
- NTIS No. PB89-216550
(Peer Review 07/14/1987)
Long-Term Carcinogenicity
- 2-YEAR (Gavage)
(C54911) Report Complete
- TR-335 (NTIS No. PB89-216550)
(Peer Review 07/14/1987)
Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats Clear Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0,375,750 MG/KG MM: 0,125,250 MG/KG FM: 0,250,500 MG/KG/50 PER GROUP
- TR-335 (NTIS No. PB89-216550)
(Peer Review 07/14/1987)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(835697) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Salmonella
(537306) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Positive
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