Testing Status of Agents at NTP
2-Nitro-p-phenylenediamine
CASRN: 5307-14-2
Formula: C6 H7 N3 O2
Synonyms/Common Names:
- 2-NITRO-1,4-BENZENEDIAMINE
Known Uses:
IN DYEING FURS, SEMI-PERMANENT AND PERMANENT HAIR DYES (HSDB 1990).
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C02222) Completed
- NTIS No. PB290304
(Peer Review 08/31/1978)
Citation: Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB290304
(Peer Review 08/31/1978)
- 13-Week (Dosed-Feed)
(C02222) Completed
- NTIS No. PB290304
(Peer Review 08/31/1978)
Citation: Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,315,6800, M: 0,810,11830 PPM/5 PER GROUP
- NTIS No. PB290304
(Peer Review 08/31/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C02222) Report Complete
- TR-169 (NTIS No. PB290304)
(Peer Review 08/31/1978)
Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Positive
- Dose: MR: 0,550,1100, FR: 0,1100,2200, M: 0,2200,4400 PPM/50 PER GROUP
- TR-169 (NTIS No. PB290304)
(Peer Review 08/31/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(186397) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Mouse Lymphoma (NCI)
(G10538) Completed
- Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
- Mouse Lymphoma-NCI Positive
- Mouse Lymphoma (NCI)
(G41276) Completed
- Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
- Mouse Lymphoma-NCI Positive
- Salmonella (NCI)
(N-9229) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(987998) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
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