Testing Information

Testing Status of Agents at NTP

D & C red no. 9

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http://ntp.niehs.nih.gov/go/TS-10729-X

CASRN: 5160-02-1

Formula: C17-H13-CL-N2-O4-S.1/2BA

Synonyms/Common Names:

  • 5-CHLORO-2-((2-HYDROXY-1-NAPHTHALENYL)AZO)-4-METHYLBENZENESULFONIC ACID, BARIUM SALT (2:1) (9CI)
  • RED NO. 9, D&C

Known Uses:

PIGMENT IN TOPICAL DRUGS AND COSMETICS

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C53792) Completed 
    • NTIS No. PB82-229592  (Peer Review 02/18/1981)
      Citation: Carcinogenesis Bioassay of D & C Red No. 9 (CAS No. 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C53792) Completed 
    • NTIS No. PB82-229592  (Peer Review 02/18/1981)
      Citation: Carcinogenesis Bioassay of D & C Red No. 9 (CAS No. 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,3000,50000, M: 0,600,10000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C53792) Report Complete 
    • TR-225 (NTIS No. PB82-229592)  (Peer Review 02/18/1981)
      Carcinogenesis Bioassay of D & C Red No. 9 (CAS No. 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0,1000,3000, M: 0,1000,2000 PPM/50 PER GROUP

Genetic Toxicology

  • Chromosome Aberrations  (832755) Completed 
    • Mice
    • Chromosome Aberation  Negative 
  • In Vitro Cytogenetics (CA/SCE)  (794744) Completed 
    • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Drosophila  (829033) Completed 
    • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Mouse Lymphoma  (494246) Completed 
    • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
    •  Negative 
  • Salmonella  (358382) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Weakly Positive 
  • Sister Chromatid Exchanges  (832755) Completed 
    • Mice
    • Sister Chromatid  Positive 

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Web page last updated on January 22, 2009