National Toxicology Program

CASRN: 3165-93-3

Formula: C7 H8 CL N.CL H

Synonyms/Common Names:

• RED BASE IRGA IX

Known Uses:

DYE INTERMEDIATE

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C02368) Completed 
  • NTIS No. PB295864  (Peer Review 12/13/1978)
    Citation: Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 3165-93-3)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,6200,50000, M: 0,15000,20000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C02368) Report Complete 
  • TR-165 (NTIS No. PB295864)  (Peer Review 12/13/1978)
    Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CAS No. 3165-93-3)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R&FM: 0,1250,5000, MM: 0,3750,15000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (333979) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (151592) Completed 
  •  Positive 
• Salmonella  (402517) Completed 
  •  Inconclusive 
• Salmonella  (721054) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Negative