National Toxicology Program

CASRN: 2871-01-4

Formula: C8-H11-N3-O3

Synonyms/Common Names:

• 2-((4-AMINO-2-NITROPHENYL)AMINO)ETHANOL (9CI)
• RED 3, HC

Known Uses:

DYE IN SEMI-PERMANENT HAIR DYES. (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C54922) Completed 
  • NTIS No. PB86-188075  (Peer Review 03/29/1985)
    Citation: Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CAS No. 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C54922) Completed 
  • NTIS No. PB86-188075  (Peer Review 03/29/1985)
    Citation: Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CAS No. 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,62,1000, M: 0,15,250 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C54922) Report Complete 
  • TR-281 (NTIS No. PB86-188075)  (Peer Review 03/29/1985)
    Toxicology and Carcinogenesis Studies of HC Red No. 3 [2,((Amino-2-nitrophenyl)amino)ethanol] (CAS No. 2871-01-4) In F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice Inadequate Study 
  • Dose: R: 0,250,500, M: 0,125,250 MG/KG/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (828169) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Mouse Lymphoma  (063330) Completed 
  •  Positive 
• Salmonella  (890915) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive