National Toxicology Program

CASRN: 2783-94-0

Formula: C16 H12 N2 O7 S2.2NA

Synonyms/Common Names:

• 6-HYDROXY-5-((4-SULFOPHENYL)AZO)-2-NAPHTHALENESULFONIC ACID DISODIUM SALT (9CI)
• SUNSET YELLOW FCF
• YELLOW NO. 6, FD & C

Known Uses:

PROVISIONALLY LISTED FOR USE IN FOOD, DRUGS, AND COSMETICS.

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C53907) Completed 
  • NTIS No. PB82-117433  (Peer Review 06/27/1980)
    Citation: Carcinogenesis Bioassay of FD & C Yellow No. 6 (CAS No. 2783-94-0)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C53907) Completed 
  • NTIS No. PB82-117433  (Peer Review 06/27/1980)
    Citation: Carcinogenesis Bioassay of FD & C Yellow No. 6 (CAS No. 2783-94-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,6000,100000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C53907) Report Complete 
  • TR-208 (NTIS No. PB82-117433)  (Peer Review 06/27/1980)
    Carcinogenesis Bioassay of FD & C Yellow No. 6 (CAS No. 2783-94-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,12500,25000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (848256) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (356840) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Inconclusive 
• Drosophila  (948568) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (030453) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Micronucleus  (029483) Completed 
  • Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (098811) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 
• Sister Chromatid Exchanges  (848256) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)