Testing Status of Agents at NTP
C.I. Direct blue 15
CASRN: 2429-74-5
Formula: C34-H28-N6-O16-S4.4Na
Synonyms/Common Names:
- BLUE 15, C.I. DIRECT
- 3,3'-((3,3'-DIMETHOXY(1,1'-BIPHENYL)-4,4'-DIYL)BIS(AZO))BIS(5-AMINO-4-HYDROXY)-2,7-NAPTHALENE DISULFONIC ACID TETRASODIUM SALT (9CI)
Known Uses:
DYE FOR SILK, WOOL, VISCOSE, LEATHER, PAPER, CELLULOSE FIBERS. BIOLOGICAL STAIN. TINT FOR CINEMATOGRAPHIC FILMS. (TDB)
Short-Term Toxicity
- 14-Day (Dosed-Water)
(C61290) Completed
- NTIS No. PB93-126373
(Peer Review 11/19/1990)
Citation: Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies) - Rats: F344/N
- NTIS No. PB93-126373
(Peer Review 11/19/1990)
- 13-Week (Dosed-Water)
(C61290) Completed
- NTIS No. PB93-126373
(Peer Review 11/19/1990)
Citation: Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies) - Rats: F344/N
- Dose: MR: 0, 1250, 2500, 5000, 10000, 30000 PPM (10 PER GROUP) FR: 0, 630, 1250, 2500, 5000, 10000 PPM (10 PER GROUP)
- NTIS No. PB93-126373
(Peer Review 11/19/1990)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Water)
(C61290) Report Complete
- TR-397 (NTIS No. PB93-126373)
(Peer Review 11/19/1990)
Toxicology and Carcinogenesis Studies of C.I. Direct Blue 15 (CAS No. 2429-74-5) in F344 Rats (Drinking Water Studies) - Rats: F344/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Dose: RATS ONLY: 0,630,1250,2500 PPM (70,45,75,70 PER GROUP RESPECTIVELY)
- TR-397 (NTIS No. PB93-126373)
(Peer Review 11/19/1990)
Special Studies
- Metabolism (Gavage)
(S0018) Completed
- Citation: LYNN, RK, DONIELSON, DW, ILIAS, AM, KENNISH, JM, WONG,K & MATTHEWS, HB: METABOLISM OF BISAZOBIPHENYL DYES DERIVED FROM BENZIDINE, 3,3'-DIMETHYLBENZIDINE OR 3,3'-DIMETHOXYBENZIDINE TO CARCINOGENIC AROMATIC AMINES IN THE DOG & RAT. TOXICOL APPL PHARMACOL, 56:248-258,1980.
- F Dog; M Rats: Sprague Dawley
- Dose: DOGS: 100 MG/KG; RATS 100 MG/KG
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(279945) Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Salmonella
(191506) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
- Salmonella Reduction
(439816) Completed
- Citation: Reid, T., Morton K., and King, C. Mutagenicity of azo dyes following metabolism by different reductive/oxidative systems. Environ. Mutagen. Vol. 6 (1984) 705-717
- Positive
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