National Toxicology Program

CASRN: 2385-85-5

Formula: C10-CL12

Synonyms/Common Names:

• 1,1A,2,2,3,3A,4,5,5,5A,5B,6-DODECACHLOROOCTAHYDRO-1,3,4-METHENO-1H-CYCLOBUTA(CD)PENTALENE (9CI)

Known Uses:

PESTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C06428A) Completed 
  • NTIS No. PB90-241084  (Peer Review 03/04/1987)
    Citation: Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclouta[cd]pentalene) (CAS No. 2385-85-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N
• 26-WEEK (Dosed-Feed)  (C06428A) Completed 
  • NTIS No. PB90-241084  (Peer Review 03/04/1987)
    Citation: Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclouta[cd]pentalene) (CAS No. 2385-85-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C06428A) Report Complete 
  • TR-313 (NTIS No. PB90-241084)  (Peer Review 03/04/1987)
    Toxicology and Carcinogenesis Studies of Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclouta[cd]pentalene) (CAS No. 2385-85-5) in F344/N Rats (Feed Studies)
  • Rats: F344/N; Rats: F344/N
  • Carcinogenesis Results
  • Male Rats Clear Evidence 
  • Female Rats Clear Evidence 
  • Dose: MR&FR:0,0.1,1,10,25, 50 (2ND STUDY) FR:0, 50,100 PPM/52 PER GROUP

Special Studies

• Cell Proliferation (Dosed-Feed)  (S0164) Completed 
  • Citation: YARBROUGH, J., CUNNINGHAM, M., YAMANAKA, H., THURMAN, R. & BADR, M.: CARBOHYDRATE & OXYGEN METABOLISM DURING HEPATOCELLULAR PROLIFERATION: A STUDY IN PERFUSED LIVERS FROM MIREX-TREATED RATS, HEPATOLOGY, 13(6):1229-1234, 1991.
  • M Rats: Sprague Dawley
  • Dose: 100 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (473171) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (109625) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative