National Toxicology Program

CASRN: 1955-45-9

Formula: C5 H8 O2

Synonyms/Common Names:

• 3,3-DIMETHYL-2-OXETANONE (9CI)

Known Uses:

INTERMEDIATE FOR POLYMERS

Short-Term Toxicity

• 14-Day (Gavage)  (C04126) Completed 
  • NTIS No. PB287645  (Peer Review 06/29/1978)
    Citation: Bioassay of Pivalolactone for Possible Carcinogenicity (CAS No. 1955-45-9)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C04126) Completed 
  • NTIS No. PB287645  (Peer Review 06/29/1978)
    Citation: Bioassay of Pivalolactone for Possible Carcinogenicity (CAS No. 1955-45-9)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,316,1470, M: 0,68,316 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Gavage)  (C04126) Report Complete 
  • TR-140 (NTIS No. PB287645)  (Peer Review 06/29/1978)
    Bioassay of Pivalolactone for Possible Carcinogenicity (CAS No. 1955-45-9)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,150,300, M: 0,75,150 MG/KG/50 PER GROUP

Genetic Toxicology

• Salmonella (NCI)  (N-9254) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive