National Toxicology Program

CASRN: 1897-45-6

Formula: C8-CL4-N2

Synonyms/Common Names:

• 2,4,5,6-TETRACHLORO-1,3-BENZENEDICARBONITRILE (9CI)

Known Uses:

FUNGICIDE, BACTERICIDE, NEMATOCIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00102) Completed 
  • NTIS No. PB286369  (Peer Review 06/29/1978)
    Citation: Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00102) Completed 
  • NTIS No. PB286369  (Peer Review 06/29/1978)
    Citation: Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,1250,20000, M: 0,1250,40000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00102) Report Complete 
  • TR-041 (NTIS No. PB286369)  (Peer Review 06/29/1978)
    Bioassay of Chlorothalonil for Possible Carcinogenicity (CAS No. 1897-45-6)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,5063,10126 (AVG), FM: 0,3000,6000 (AVG), MM: 0,2688,5375 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (739007) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (315727) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Mouse Lymphoma  (351015) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (323726) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative