National Toxicology Program

CASRN: 1634-78-2

Formula: C10 H19 O7 P S

Synonyms/Common Names:

• ((DIMETHOXYPHOSPHINYL)THIO)-BUTANEDIOIC ACID, DIETHYL ESTER (9CI)

Known Uses:

METABOLITE OF MALATHION

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C08628) Completed 
  • NTIS No. PB299858  (Peer Review 05/01/1979)
    Citation: Bioassay of Malaoxon for Possible Carcinogenicity (CAS No. 1634-78-2)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C08628) Completed 
  • NTIS No. PB299858  (Peer Review 05/01/1979)
    Citation: Bioassay of Malaoxon for Possible Carcinogenicity (CAS No. 1634-78-2)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,125,8000 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C08628) Report Complete 
  • TR-135 (NTIS No. PB299858)  (Peer Review 05/01/1979)
    Bioassay of Malaoxon for Possible Carcinogenicity (CAS No. 1634-78-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,500,1000 PPM/50 PER GROUP

Genetic Toxicology

• Chromosome Aberrations  (635239) Completed 
  • Mice
  • Chromosome Aberation  Negative 
• In Vitro Cytogenetics (CA/SCE)  (725067) Completed 
  • Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in Vitro IV: Results for l5 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• Drosophila  (099462) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Sex-Linked Recessive Lethal Positive 
  • Reciprocal Translocation Negative 
• Mouse Lymphoma  (566519) Completed 
  • Citation: Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
  •  Positive 
• Salmonella  (822824) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Negative 
• Sister Chromatid Exchanges  (635239) Completed 
  • Mice
  • Sister Chromatid  Negative (Nonstandard Protocol)